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DNA sequencing part 2: ligases and PCR

In our last installment on DNA sequencing, we brought you up to speed on the Sanger method of sequencing (named after its dual-Nobel-winning inventor, Fred Sanger), which was state-of-the-art around the time of the completion of the human genome. That was about five years ago. During a visit last month to the Broad Institute, which does genome sequencing, my hosts made it clear that, while Sanger sequencing still had its uses, th....

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